Kiyoshi Fukui Selected Research

D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)

9/2021	Dynamics of D-amino acid oxidase ain kidney epithelial cells under amino acid starvation.
11/2020	P219L substitution in human D-amino acid oxidase impacts the ligand binding and catalytic efficiency.
6/2017	Elucidation of inhibitor-binding pockets of d-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology.
12/2015	Identification of DNA-binding proteins that interact with the 5'-flanking region of the human D-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry.
6/2014	Evaluation of human D-amino acid oxidase inhibition by anti-psychotic drugs in vitro.
10/2009	Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain.
12/2008	Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia.
12/2006	Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring.
4/2006	Characterization of human D-amino acid oxidase.

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Kiyoshi Fukui Research Topics

Disease

9	Schizophrenia (Dementia Praecox) 06/2017 - 04/2006
3	Necrosis 01/2017 - 01/2012
3	Parkinson Disease (Parkinson's Disease) 04/2007 - 05/2006
2	Hepatitis 01/2012 - 03/2010
1	Starvation 09/2021
1	Virus Diseases (Viral Diseases) 07/2021
1	Human Influenza (Influenza) 07/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2020
1	Influenza in Birds (Avian Flu) 01/2016
1	Glioblastoma (Glioblastoma Multiforme) 12/2015
1	Breast Neoplasms (Breast Cancer) 10/2015
1	Reperfusion Injury 01/2013

Drug/Important Bio-Agent (IBA)

9	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 09/2021 - 04/2006
4	Proteins (Proteins, Gene)FDA Link 09/2021 - 12/2006
4	Serine (L-Serine)FDA Link 06/2017 - 04/2006
3	Amino Acids FDA Link 09/2021 - 10/2009
2	Flavin-Adenine Dinucleotide (FAD)IBA 06/2017 - 12/2006
2	Dihydroxyphenylalanine (Dopa)IBA 04/2007 - 01/2007
2	Dopamine (Intropin)FDA LinkGeneric 04/2007 - 01/2007
2	N-Methylaspartate (NMDA)IBA 12/2006 - 04/2006
2	Glutamate Receptors (Glutamate Receptor)IBA 12/2006 - 04/2006
1	Oseltamivir (Tamiflu)FDA Link 07/2021
1	Neuraminidase (Sialidase)IBA 07/2021
1	Caspase 9IBA 01/2017
1	NucleotidesIBA 01/2017
1	Antipsychotic Agents (Antipsychotics)IBA 06/2014
1	CytokinesIBA 01/2013
1	Interleukin-6 (Interleukin 6)IBA 01/2013
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2013
1	InterleukinsIBA 01/2013
1	Cysteine (L-Cysteine)FDA Link 01/2013
1	Alanine Transaminase (SGPT)IBA 01/2012
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2012
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2012
1	NF-kappa B (NF-kB)IBA 03/2010
1	Chlorpromazine (Thorazine)FDA Link 12/2008
1	EnzymesIBA 12/2006
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 05/2006

Therapy/Procedure

2	Therapeutics 06/2017 - 10/2015